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구강생리학교실
조교수
-
- 전공
- 구강생리학 / 타액선생리학 및 타액선재생의학
-
- 학위
- D.D.S.， Ph.D.
-
- 전화번호
- +82-10-2932-0902
-
- Laboratory
- +82-02-740-8659
학력사항
-
- 2013 - 2018
- Ph.D. 서울대학교 치의학대학원 (DDS-PhD 복합학위과정, 치의과학)
-
- 2011 - 2015
- D.D.S. 서울대학교 치의학대학원 (DDS-PhD 복합학위과정, 치의학)
-
- 2006 - 2010
- B.S. KAIST (생명과학)
경력사항
-
- 2022 - 현재
- 조교수, 서울대학교 치의학대학원 치의과학과 구강생리학교실
-
- 2021 - 2022
- 연구조교수, 서울대학교 치의학대학원 치아-치주 복합체 연구센터
연구분야
I mainly study salivary gland physiology, but my research is also highly multi-disciplinary covering salivary gland morphogenesis, regeneration, nanozyme, tissue engineering, Sjogren's syndrome, and general bioengineering. Saliva, one of the most important bodily fluids, is produced by the salivary glands. Salivary gland dysfunction leads to hyposalivation or xerostomia, which causes the deterioration of both oral and systemic health. Therefore, it is highly desirable to develop therapeutics to regenerate or replace damaged salivary gland tissues.
My first goal is to elucidate key factors involved in branching morphogenesis of developing embryonic salivary glands. Since the process of regeneration recapitulates developmental process, our team is testing whether those newly discovered morphogens have regenerative potential in salivary glands. My second research goal is to engineer such regenerative or protective factors with cutting-edge nanotechnology and biomimetic approaches, enhancing and optimizing their bioactivity for industrialization and clinical application. Therefore, development and application of new types of nanozymes or biomaterials is another wing of our research interest. Lastly, we are trying to apply those discovered salivary gland regenerative/ protective factors on other epithelial organs such as intestine, kidney, lung, and pancreas. I believe that salivary gland will become a key organ bridging orofacial area and entire body system, allowing us to expand field of dentistry.
My first goal is to elucidate key factors involved in branching morphogenesis of developing embryonic salivary glands. Since the process of regeneration recapitulates developmental process, our team is testing whether those newly discovered morphogens have regenerative potential in salivary glands. My second research goal is to engineer such regenerative or protective factors with cutting-edge nanotechnology and biomimetic approaches, enhancing and optimizing their bioactivity for industrialization and clinical application. Therefore, development and application of new types of nanozymes or biomaterials is another wing of our research interest. Lastly, we are trying to apply those discovered salivary gland regenerative/ protective factors on other epithelial organs such as intestine, kidney, lung, and pancreas. I believe that salivary gland will become a key organ bridging orofacial area and entire body system, allowing us to expand field of dentistry.
연구방법
1. Elucidation of key mechanisms of salivary gland branching morphogenesis
2. Engineering and optimization of salivary gland regenerative factors for clinical application
3. Applying biological findings from salivary gland research to other epithelial organs
[ Key Words ] Salivary gland; Branching morphogenesis; Nanozyme; Tissue engineering; Organoid; Sjogren's syndrome
2. Engineering and optimization of salivary gland regenerative factors for clinical application
3. Applying biological findings from salivary gland research to other epithelial organs
[ Key Words ] Salivary gland; Branching morphogenesis; Nanozyme; Tissue engineering; Organoid; Sjogren's syndrome
연구목록
- Sang-woo Lee(2024-01-08). The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA. International Journal of Molecular Sciences. 25(15)
- Sang-woo Lee(2024-01-01). Antimicrobial adhesive self-healing hydrogels for efficient dental biofilm removal from periodontal tissue. Dental Materials. 40(11)1970-1980
- Sang-woo Lee, Gehoon Chung(2024-01-01). Loss of dental pulp potentially increased the risk of Alzheimer's dementia. Journal of Dental Sciences. 20(1)310-318
- Sang-woo Lee, Young Jun Lim, Ho-Beom Kwon, Myung-Joo Kim(2023-10-06). Manganese Oxide Nanozyme-Doped Diatom for Safe and Efficient Treatment of Peri-Implantitis. ACS Applied Materials and Interfaces, ACS applied materials & interfaces. 14(24)27634-27650
- Sang-woo Lee, Ho-Beom Kwon, Young Jun Lim, Myung-Joo Kim(2023-01-12). Antimicrobial efficacy of self-locomotive manganese oxide nanozyme-doped diatom microbubbler on orthodontic brackets in vitro. BMC Oral Health. 23(1)
- Sang-woo Lee(2022-05-01). NiCHE Platform. ACS Applied Materials and Interfaces, ACS applied materials & interfaces. 12(4)4285-4294
- Sang-woo Lee(2022-01-03). Clinical and histopathologic characteristics of submandibular gland in Stevens-Johnson syndrome. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Oral Surgery Oral Medicine and Oral Pathology. 133(3)326-332
- Sang-woo Lee(2021-02-04). Efficient surface immobilization of chemically modified hyaluronans for enhanced bioactivity and survival of in vitro-cultured embryonic salivary gland mesenchymal cells. Polymers. 13(8)
- Sang-woo Lee(2021-02-01). CXCR4 regulates temporal differentiation via PRC1 complex in organogenesis of epithelial glands. International Journal of Molecular Sciences. 22(2)1-21
- Sang-woo Lee(2021-01-11). High glucose reduces the paracellular permeability of the submandibular gland epithelium via the mir-22-3p/sp1/claudin pathway. Cells. 10(11)
- Sang-woo Lee(2021-01-10). FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland. Journal of Dental Research. 100(11)1281-1288
- Sang-woo Lee, Jin-Man Kim(2021-01-03). LPS-induced epithelial barrier disruption via hyperactivation of CACC and ENaC. American Journal of Physiology - Cell Physiology. 320(3)C448-C461
- Sang-woo Lee(2020-01-10). Developmental role of hyaluronic acid and its application in salivary gland tissue engineering. Acta Biomaterialia. 115()275-287
- Sang-woo Lee(2020-01-08). Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection. Advanced Materials. 32(31)
- Sang-woo Lee(2019-02-12). Epigenetic modification as a regulatory mechanism for spatiotemporal dynamics of ANO1 expression in salivary glands. International Journal of Molecular Sciences. 20(24)
- Sang-woo Lee(2018-01-12). Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth /631/80/86/1999 /631/136/2091 /13 /13/51 /13/106 /14/19 /14/32 /14/34 /64 /64/60 article. Scientific Reports. 8(1)
- Sang-woo Lee(2018-01-11). Highly conductive, stretchable and biocompatible Ag?Au core?sheath nanowire composite for wearable and implantable bioelectronics. Nature Nanotechnology. 13(11)1048-1056
- Sang-woo Lee(2018-01-10). Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sj?gren's syndrome. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864(10)3154-3163
- Sang-woo Lee, Youngnim Choi(2017-01-10). Effect of anti-muscarinic autoantibodies on leukocyte function in Sj?gren's syndrome. Molecular Immunology, Immunochemistry. 90()136-142
- Sang-woo Lee(2017-01-01). P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer. Oncotarget. 8(30)48972-48982
- Sang-woo Lee, Se-Young Choi(2016-02-12). Epigenetic regulation of CFTR in salivary gland. Biochemical and Biophysical Research Communications. 481(1-2)31-37
- Sang-woo Lee(2011-01-04). Enzyme-mediated cross-linking of Pluronic copolymer micelles for injectable and in situ forming hydrogels. Acta Biomaterialia. 7(4)1468-1476
구강생리학교실
조교수
-
- 전공
- 구강생리학 / 타액선생리학 및 타액선재생의학
-
- 학위
- D.D.S.， Ph.D.
-
- 전화번호
- +82-10-2932-0902
-
- Laboratory
- +82-02-740-8659
학력사항
-
- 2013 - 2018
- Ph.D. 서울대학교 치의학대학원 (DDS-PhD 복합학위과정, 치의과학)
-
- 2011 - 2015
- D.D.S. 서울대학교 치의학대학원 (DDS-PhD 복합학위과정, 치의학)
-
- 2006 - 2010
- B.S. KAIST (생명과학)
경력사항
-
- 2022 - 현재
- 조교수, 서울대학교 치의학대학원 치의과학과 구강생리학교실
-
- 2021 - 2022
- 연구조교수, 서울대학교 치의학대학원 치아-치주 복합체 연구센터
연구분야
I mainly study salivary gland physiology, but my research is also highly multi-disciplinary covering salivary gland morphogenesis, regeneration, nanozyme, tissue engineering, Sjogren's syndrome, and general bioengineering. Saliva, one of the most important bodily fluids, is produced by the salivary glands. Salivary gland dysfunction leads to hyposalivation or xerostomia, which causes the deterioration of both oral and systemic health. Therefore, it is highly desirable to develop therapeutics to regenerate or replace damaged salivary gland tissues.
My first goal is to elucidate key factors involved in branching morphogenesis of developing embryonic salivary glands. Since the process of regeneration recapitulates developmental process, our team is testing whether those newly discovered morphogens have regenerative potential in salivary glands. My second research goal is to engineer such regenerative or protective factors with cutting-edge nanotechnology and biomimetic approaches, enhancing and optimizing their bioactivity for industrialization and clinical application. Therefore, development and application of new types of nanozymes or biomaterials is another wing of our research interest. Lastly, we are trying to apply those discovered salivary gland regenerative/ protective factors on other epithelial organs such as intestine, kidney, lung, and pancreas. I believe that salivary gland will become a key organ bridging orofacial area and entire body system, allowing us to expand field of dentistry.
My first goal is to elucidate key factors involved in branching morphogenesis of developing embryonic salivary glands. Since the process of regeneration recapitulates developmental process, our team is testing whether those newly discovered morphogens have regenerative potential in salivary glands. My second research goal is to engineer such regenerative or protective factors with cutting-edge nanotechnology and biomimetic approaches, enhancing and optimizing their bioactivity for industrialization and clinical application. Therefore, development and application of new types of nanozymes or biomaterials is another wing of our research interest. Lastly, we are trying to apply those discovered salivary gland regenerative/ protective factors on other epithelial organs such as intestine, kidney, lung, and pancreas. I believe that salivary gland will become a key organ bridging orofacial area and entire body system, allowing us to expand field of dentistry.
연구방법
1. Elucidation of key mechanisms of salivary gland branching morphogenesis
2. Engineering and optimization of salivary gland regenerative factors for clinical application
3. Applying biological findings from salivary gland research to other epithelial organs
[ Key Words ] Salivary gland; Branching morphogenesis; Nanozyme; Tissue engineering; Organoid; Sjogren's syndrome
2. Engineering and optimization of salivary gland regenerative factors for clinical application
3. Applying biological findings from salivary gland research to other epithelial organs
[ Key Words ] Salivary gland; Branching morphogenesis; Nanozyme; Tissue engineering; Organoid; Sjogren's syndrome
연구목록
- Sang-woo Lee(2024-01-08). The Aryl Hydrocarbon Receptor Regulates Invasiveness and Motility in Acute Myeloid Leukemia Cells through Expressional Regulation of Non-Muscle Myosin Heavy Chain IIA. International Journal of Molecular Sciences. 25(15)
- Sang-woo Lee(2024-01-01). Antimicrobial adhesive self-healing hydrogels for efficient dental biofilm removal from periodontal tissue. Dental Materials. 40(11)1970-1980
- Sang-woo Lee, Gehoon Chung(2024-01-01). Loss of dental pulp potentially increased the risk of Alzheimer's dementia. Journal of Dental Sciences. 20(1)310-318
- Sang-woo Lee, Young Jun Lim, Ho-Beom Kwon, Myung-Joo Kim(2023-10-06). Manganese Oxide Nanozyme-Doped Diatom for Safe and Efficient Treatment of Peri-Implantitis. ACS Applied Materials and Interfaces, ACS applied materials & interfaces. 14(24)27634-27650
- Sang-woo Lee, Ho-Beom Kwon, Young Jun Lim, Myung-Joo Kim(2023-01-12). Antimicrobial efficacy of self-locomotive manganese oxide nanozyme-doped diatom microbubbler on orthodontic brackets in vitro. BMC Oral Health. 23(1)
- Sang-woo Lee(2022-05-01). NiCHE Platform. ACS Applied Materials and Interfaces, ACS applied materials & interfaces. 12(4)4285-4294
- Sang-woo Lee(2022-01-03). Clinical and histopathologic characteristics of submandibular gland in Stevens-Johnson syndrome. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Oral Surgery Oral Medicine and Oral Pathology. 133(3)326-332
- Sang-woo Lee(2021-02-04). Efficient surface immobilization of chemically modified hyaluronans for enhanced bioactivity and survival of in vitro-cultured embryonic salivary gland mesenchymal cells. Polymers. 13(8)
- Sang-woo Lee(2021-02-01). CXCR4 regulates temporal differentiation via PRC1 complex in organogenesis of epithelial glands. International Journal of Molecular Sciences. 22(2)1-21
- Sang-woo Lee(2021-01-11). High glucose reduces the paracellular permeability of the submandibular gland epithelium via the mir-22-3p/sp1/claudin pathway. Cells. 10(11)
- Sang-woo Lee(2021-01-10). FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland. Journal of Dental Research. 100(11)1281-1288
- Sang-woo Lee, Jin-Man Kim(2021-01-03). LPS-induced epithelial barrier disruption via hyperactivation of CACC and ENaC. American Journal of Physiology - Cell Physiology. 320(3)C448-C461
- Sang-woo Lee(2020-01-10). Developmental role of hyaluronic acid and its application in salivary gland tissue engineering. Acta Biomaterialia. 115()275-287
- Sang-woo Lee(2020-01-08). Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection. Advanced Materials. 32(31)
- Sang-woo Lee(2019-02-12). Epigenetic modification as a regulatory mechanism for spatiotemporal dynamics of ANO1 expression in salivary glands. International Journal of Molecular Sciences. 20(24)
- Sang-woo Lee(2018-01-12). Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth /631/80/86/1999 /631/136/2091 /13 /13/51 /13/106 /14/19 /14/32 /14/34 /64 /64/60 article. Scientific Reports. 8(1)
- Sang-woo Lee(2018-01-11). Highly conductive, stretchable and biocompatible Ag?Au core?sheath nanowire composite for wearable and implantable bioelectronics. Nature Nanotechnology. 13(11)1048-1056
- Sang-woo Lee(2018-01-10). Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sj?gren's syndrome. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864(10)3154-3163
- Sang-woo Lee, Youngnim Choi(2017-01-10). Effect of anti-muscarinic autoantibodies on leukocyte function in Sj?gren's syndrome. Molecular Immunology, Immunochemistry. 90()136-142
- Sang-woo Lee(2017-01-01). P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer. Oncotarget. 8(30)48972-48982
- Sang-woo Lee, Se-Young Choi(2016-02-12). Epigenetic regulation of CFTR in salivary gland. Biochemical and Biophysical Research Communications. 481(1-2)31-37
- Sang-woo Lee(2011-01-04). Enzyme-mediated cross-linking of Pluronic copolymer micelles for injectable and in situ forming hydrogels. Acta Biomaterialia. 7(4)1468-1476