한승현 Seung Hyun Han   교수 / Ph.D.
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· Major : 감염-면역학
· E-mail : shhan-mi@snu.ac.kr
· Tel : 02-880-2310
· Laboratory : 감염-면역학 연구실 홈페이지
Current Research Interests

병원성미생물에 의한 감염질환을 효과적으로 제어하기 위해서는 병원균의 인체감염기전과 이에 대응하는 인체의 면역반응에 대한 이해가 중요하다. 본 연구실은 면역학, 미생물학, 분자생물학을 기반으로, (1) 감염질환을 유발하는 병독력인자의 특성 규명과 면역반응, (2) 감염질환에 의한 파골세포/조골세포의 분화 및 기능 변화, (3) 백신 효능평가를 위한 표준시험법 개발 및 임상적용, (4) 발암물질의 면역독성 기전, (5) 줄기세포를 이용한 수지상세포 개발을 위한 연구를 수행하고 있다.


1. 병독력인자 (PAMP: Pathogen-associated molecular patterns)의 선천성면역반응
  - 병원성 vs. 비병원성 그람 양성세균의 lipoteichoic acid 구조와 선천성 면역반응
  - 주요 병독력인자들간의 상호작용과 세균성 패혈증 유발기전

2. 감염질환의 예방/치료를 위한 백신 및 세포치료제 개발
  - 백신 조성과 투여방법에 따른 특이면역반응 규명과 백신임상시험용 표준시험법 개발
  - 제대혈 줄기세포를 이용한 수지상세포 제조와 수지상세포의 면역조절기전

3. 발암물질의 면역억제 기전 규명과  항암 면역치료기술 개발
  - 발암물질과 독성물질의 면역억제기전과 특이신호전달과정 규명
  - 면역세포를 이용한 항암면역치료기술 개발

Publication / Patent

154. Mi Seon Jang, Sushant Sahastrabuddhe, Cheol-Heui Yun, Seung Hyun Han, Jae Seung Yang (2016.05). Serum bactericidal assay for the evaluation of typhoid vaccine using a semi-automated colony-counting method. Microbial Pathogenesis 97:19-26
153. Sang-Min Lim, Ki Bum Ahn, Christine Kim, Jong-Won Kum, Hiran Perinpanayagam, Yu Gu, Yeon-Jee Yoo, Seok Woo Chang, Seung Hyun Han, Won-Jun Shon, Woocheol Lee, Seung-Ho Baek, Qiang Zhu, Kee-Yeon Kum (2016.05). Antifungal effects of synthetic human β-defensin 3-C15 peptide. Restorative Dentistry & Endodontics 41(2):91-97
152. Donghyun Joo, Kwang-Hyun Cho, Seung Hyun Han, Deok-Chun Yang, Cheol-Heui Yun (2016.04). Biphasic activation of extracellular signal-regulated kinase 1/2 in epidermal growth factor-stimulated SW480 colorectal cancer cells. BMB Reports 49(4):220-225
151. Jiseon Kim, Jihyun Yang, Ok-Jin Park, Seok-Seong Kang, Cheol-Heui Yun, Seung Hyun Han (2016.04). Serum amyloid A inhibits osteoclast differentiation to maintain macrophage function. Journal of Leukocyte Biology 99: 595-603
150. Jihyun Yang, Ok-Jin Park, Jiseon Kim, Cheol-Heui Yun, Seung Hyun Han (2016.04). Lipoteichoic acid of Enterococcus faecalis inhibits the differentiation of macrophages into osteoclasts. Journal of Endodontics 42(4):570-574
149. Sushila Maharjan, Bijay Singh, Tao Jiang, So-Yeon Yoon, Hui-Shan Li, Gi Rak Kim, Min Jeong Gu, Soo Ji Kim, Ok-Jin Park, Seung Hyun Han, Sang-Kee Kang, Cheol-Heui Yun, Yun-Jaie Choi, Chong-Su Cho (2016.04). Systemic administration of RANKL overcomes the bottleneck of oral vaccine delivery through microfold cells in ileum. Biomaterials 23(84):286-300
148. Min Jeong Gu, Sun Kwang Song, In Kyu Lee, Seongyeol Ko, Seung Eun Han, Suhan Bae, Sang Yun JI, Byung-Chul Park, Ki-Duk Song, Hak-Kyo Lee, Seung Hyun Han, Cheol-Heui Yun (2016.02). Barrier protection via Toll-like receptor 2 signaling in porcine intestinal epithelial cells damaged by deoxynivalnol. Veterinary Research 47:25
147. Sun Kyung Kim, Cheol-Heui Yun, Seung Hyun Han (2015.12). Dendritic cells differentiated from human umbilical cord blood-derived monocytes exhibit tolerogenic characteristics. Stem Cells and Development 24(23):2796-2807
146. Jae Seung Yang, Hye Jin Kim, Seok-Seong Kang, Kyoung Whun Kim, Dong Wook Kim, Cheol-Heui Yun, Soon-Jung Park, Ho Seong Seo, B. Brett Finlay, Seung Hyun Han (2015.10). TLR2, but not TLR4, plays a predominant role in the immune responses to cholera vaccines. Journal of Leukocyte Biology 98(4):661-9
145. Sun-Je Woo, Seok-Seong Kang, Sung-Moo Park, Jae Seung Yang, Man Ki Song, Cheol-Heui Yun, Seung Hyun Han (2015.10). Intranasal immunization with protective antigen of Bacillus anthracis induces a long-term immunological memory response. Molecular Immunology 67(2 Pt B):492-500
144. Ok-Jin Park, Jiseon Kim, Jihyun Yang, Cheol-Heui Yun, Seung Hyun Han. Enterococcus faecalis inhibits osteoblast differentiation and induces chemokine expression. Journal of Endodontics (in press)
143. Seok-Seong Kang, Su Young Noh, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2015.09). Staphylococcus aureus induces IL-8 expression through its lipoproteins in the human intestinal epithelial cell Caco-2. Cytokine 75(1):174-180
142. Ok-Jin Park, Min-Kyung Cho, Cheol-Heui Yun, Seung Hyun Han (2015.09). Lipopolysaccharide of Aggregatibacter actinomycetemcomitans induces the expression of chemokines MCP-1, MIP-1α, and IP-10 via similar but distinct signaling pathways in murine macrophages. Immunobiology 220(9):1067-1074
141. Jintaek Im, Jung Eun Baik, Kyung Whun Kim, Seok-Seong Kang, Jun Ho Jeon, Ok-Jin Park, Hyun Young Kim, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han (2015.08). Enterococcus faecalis lipoteichoic acid suppresses Aggregatibacter actinomycetemcomitans lipopolysaccharide-induced IL-8 expression in human periodontal ligament cells. International Immunology 27(8):381-391
140. Seok-Seong Kang, Jung Eun Baik, Jae Seung Yang, Kun Cho, Cheol-Heui Yun, Seung Hyun Han (2015.07). Protein profiles in mucosal and systemic compartments in response to Vibrio cholerae in a mouse pulmonary infection model. Microbial Pathogenesis 86:10-17
139. Ok-Jin Park, Hana Yi, Jun Ho Jeon, Seok-Seong Kang, Ki-Tae Koo, Kee-Yeon Kum, Jongsik Chun, Cheol-Heui Yun, Seung Hyun Han (2015.07). Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions. Journal of Dental Research 94(7):921-927
138. Ok-Jin Park, Jihyun Yang, Jiseon Kim, Cheol-Heui Yun, Seung Hyun Han (2015.05). Enterococcus faecalis attenuates the differentiation of macrophages into osteoclasts. Journal of Endodontics 41(5):658-662
137. Jun Ho Jeon, Ki Bum Ahn, Sun Kyung Kim, Jintaek Im, Cheol-Heui Yun, Seung Hyun Han (2015.05). Bacterial flagellin induces IL-6 expression in human basophils. Molecular Immunology 65(1):168-176
136. Jung Eun Baik, Young-Oh Jang, Seok-Seong Kang, Kun Cho, Cheol-Heui Yun, Seung Hyun Han (2015.05). Differential profiles of gastrointestinal proteins interacting with peptidoglycans from Lactobacillus plantarum and Staphylococcus aureus. Molecular Immunology 65(1):77-85
135. Nam Jung Kim, Ki Bum Ahn, Jun Ho Jeon, Cheol-Heui Yun, B. Brett Finlay, Seung Hyun Han (2015.05). Lipoprotein in the cell wall of Staphylococcus aureus is a major inducer of nitric oxide production in murine macrophages. Molecular Immunology 65(1):17-24
134. Su Young Noh, Seok-Seong Kang, Cheol-Heui Yun, Seung Hyun Han (2015.03). Lipoteichoic acid from Lactobacillus plantarum inhibits Pam2CSK4-induced IL-8 production in human intestinal epithelial cells. Molecular Immunology 64(1):183-189
133. Yeo Jin Lee, Young Min Son, Min Jeong Gu, Ki-Duk Song, Sung-Moo Park, Hyo Jin Song, Jae Sung Kang, Jong Soo Woo, Jee Hyung Jung, Deok-Chun Yang, Seung Hyun Han, Cheol-Heui Yun (2015.01) Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells. Journal of Ginseng Research 39(1):29-37
132. Jun Sang Yoo, Seok-Woo Chang, So Ram Oh, Hiran Perinpanayagam, Sang-Min Lim, Yeon-Jee Yoo, Yeo-Rok Oh, Sang-Bin Woo, Seung Hyun Han, Qiang Zhu, Kee-Yeon Kum (2014.12). Bacterial entombment by intratubular mineralization following mineral trioxide aggregate obturation: a scanning electron microscope study. International Journal of Oral Science 6(4):227-232
131. Ki Bum Ahn, Jun Ho Jeon, Seok-Seong Kang, Dae Kyun Chung, Cheol-Heui Yun, Seung Hyun Han (2014.11). IgE in the absence of allergen induces the expression of monocyte chemoattractant protein-1 in the rat basophilic cell-line RBL-2H3. Molecular Immunology 62(1):114-121
130. Jannatul Firdous, Mohammad Ariful Islama, Sung-Moo Parka, In-Su Cheona, Byoung-Shik Shim, Hyo-Shin Yoon, Manki Song, Jun Chang, Yun-Jaie Choi, Yeong-Min Park, Diana Boraschi, Seung-Hyun Han, Chong-Su Cho, Cheol-Heui Yun (2014.11). Induction of long-term immunity against respiratory syncytial virus glycoprotein by an osmotic polymeric nanocarrier. Acta Biomaterialia 10(11):4606-4617
129. Sun Woong Hong, Deog-Gyu Seo, Jung Eun Baik, Kun Cho, Cheol-Heui Yun, Seung Hyun Han (2014.10). Differential profiles of salivary proteins with affinity to Streptococcus mutans lipoteichoic acid in caries-free and caries-positive human subjects. Molecular Oral Microbiology 29(5):208-218
128. Song-Hee Han, Seong-Jun Kim, Eun-Jung Kim, Tae-Eun Kim, Jae-Su Moon, Geon-Woo Kim, Seung-Hoon Lee, Kun Cho, Jong Shin Yoo, Woo Sung Son, Jin-Kyu Rhee, Seung Hyun Han, Jong-Won Oh (2014.10). Phosphorylation of hepatitis C virus RNA polymerases ser29 and ser42 by protein kinase C-related kinase 2 regulates viral RNA replication. Journal of Virology 88(19):11240-11252
127. Jintaek Im, Taeheon Lee, Jun Ho Jeon, Jung Eun Baik, Kyoung Whun Kim, Seok-Seong Kang, Cheol-Heui Yun, Heebal Kim, Seung Hyun Han (2014.07). Gene expression profiling of bovine mammary gland epithelial cells stimulated with lipoteichoicacid plus peptidoglycan from Staphylococcus aureus. International Immunopharmacology 21(1):231-240
126. Jae Seung Yang, Seok-Seong Kang, Cheol-Heui Yun, Seung Hyun Han (2014.06). Evaluation of anticoagulants for serologic assays of cholera vaccination. Clinical and Vaccine Immunology 21(6):854-858
125. Se-Ra Park, Dong-Jae Kim, Seung Hyun Han, Min-Jung Kang, Jun-Young Lee, Yu-Jin Jeong, Sang-Jin Lee, Tae-Hyoun Kim, Sang-Gun Ahn, Jung-Hoon Yoon, Jong-Hwan Park (2014.05). Diverse toll-like receptors mediate cytokines production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages. Infection and Immunity 82(5):1914-1920
124. In Kyu Lee, Young Min Son, Young Jun Ju, Sun Kwang Song, Min Jung Gu, Ki-Duk Song, Hwi-Cheul Lee, Jae-Seok Woo, Jae Goo Seol, Sung Moo Park, Seung Hyun Han, Cheol-Heui Yun (2014.03). Survival of porcine fibroblasts enhanced by human FasL and dexamethasone-treated human dendritic cells in vitro. Transplant Immunology 30(2-3):99-106
123. Ki Bum Ahn, Jun Ho Jeon, Jung Eun Baik, Ok-Jin Park, Seok-Seong Kang, Cheol-Heui Yun, Jong-Hwan Park, Seung Hyun Han (2014.02). Muramyl dipeptide potentiates staphylococcal lipoteichoic acid induction of cyclooxygenase-2 in murine macrophages. Microbes and Infection 16(2):153-160
122. Sun Woong Hong, Jung Eun Baik, Cheol-Heui Yun, Deog-Gyu Seo, Seung Hyun Han (2014.02). Lipoteichoic acid of Streptococcus mutans interacts with Toll-like receptor 2 through the lipid moiety for induction of inflammatory mediators in murine macrophages. Molecular Immunology 57(2):284-291
121. Kyong Hoon Kim, Seung-min Yeon, Hyun Gyung Kim, Hwanbum Lee, Sun Kyung Kim, Seung Hyun Han, Kyung-Jin Min, Youngjoo Byun, Eun Hee Lee, Kenneth Sung Lee, Soon Hong Yuk, Un-Hwan Ha, Yong Woo Jung (2014.02). Single-walled nanotubes induce cell death and transcription of TNF-α in macrophages without affecting nitric oxide production. Inflammation 37(1):44-54
120. In Su Cheon, Sung-Moo Park, Hye Jin Lee, Ji Eun Hong, Sang Yun Ji, Byoung-Shik Shima, Kwang Ho Kim, Pil Seung Heo, Yoo Yong Kim, Hyun Jung Jung, Hakhyun Ka, Seung Hyun Han, Manki Song, Cheol-Heui Yun (2014.02). Functional characteristics of porcine peripheral T cells stimulated with IL-2 or IL-2 and PMA. Research in Veterinary Science 96(1):54-61
119. Ok-Jin Park, Ji Young Han, Jung Eun Baik, Jun Ho Jeon, Seok-Seong Kang, Cheol-Heui Yun, Jong-Won Oh, Seung Hyun Han (2013.12). Lipoteichoic acid of Enterococcus faecalis induces the of chemokines via TLR2 and PAFR signaling pathways. Journal of Leukocyte Biology 94(6):1275-1284
118. Jin-Kyung Lee, Seok Woo Chang, Hiran Perinpanayagam, Sang-Min Lim, Yoon-Jeong Park, Seung Hyun Han, Seung-Ho Baek, Qiang Zhu, Kwang-Shik Bae, Kee-Yeon Kum (2013.12). Antibacterial efficacy of a human β-defensin-3 peptide on multispecies biofilms. Journal of Endodontics 39(12):1625-1629
117. Wooseong Lee, Seung-Hoon Lee, Dae-Gyun Ahn, Hee Cho, Moon-Hee Sung, Seung Hyun Han, Jong-Won Oh (2013.12). The antiviral activity of poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., through induction of CD14-dependent type I interferon responses. Biomaterials 34(37):9700-9708
116. Jiseon Kim, Jihyun Yang, Ok-Jin Park, Seok-Seong Kang, Woo-Shin Kim, Kenji Kurokawa, Cheol-Heui Yun, Hong-Hee Kim, Bok Luel Lee, Seung Hyun Han (2013.11). Lipoproteins are an important bacterial component responsible for bone destruction through the induction of osteoclast differentiation and activation. Journal of Bone and Mineral Research 28(11):2381-2391
115. Bo-Young Hong, Tae-Kwon Lee, Sang-Min Lim, Seok Woo Chang, Joon hong Park, Seung Hyun Han, Qiang Zhu, Kamran E. Safavi, Ashraf F. Fouad, Kee Yeon Kum (2013.09). Microbial analysis in primary and persistent endodontic infections by using pyrosequencing. Journal of Endodontics 39(9):1136-1140.
114. Hyuk Chu, Sung-Moo Park, In Su Cheon, Byoung-Shik Shim, Woon Hee Jeung, Ki-Duk Song, Manki Song, Kee-Jong Hong, Kyu-Jam Hwang, Mi-Yeoun Park, Byoung-Cheol Gil, Hang-Jin Jeong, Seung Hyun Han, Cheol-Heui Yun (2013.08). Orientia tsutsugamushi infection induces CD4+ T cell activation via human dendritic cell activity. Journal of Microbiology and Biotechnology 23(8):1159-1166
113. Seok-Seong Kang, Jae Seung Yang, Kyoung Whun Kim, Cheol-Heui Yun, Jan Holmgren, Cecil Czerkinsky, Seung Hyun Han (2013.07). Anti-bacterial and anti-toxic immunity induced by a killed whole cell-cholera toxin B subunit cholera vaccine is essential for protection against lethal bacterial infection in mouse pulmonary cholera model. Mucosal Immunology 6(4):826-837
112. Sun Kyung Kim, Cheol-Heui Yun, Seung Hyun Han (2013.07). Enhanced anti-cancer activity of human dendritic cells sensitized with gamma-irradiation-induced apoptotic colon cancer cells. Cancer Letters 335(2):278-288
111. Young Min Son, Ki-Duk Song, Sung-Moo Park, Seung Hyun Han, Cheol-Heui Yun (2013.07). Lipoteichoic acid suppresses effector T cells induced by Staphylococcus aureus-pulsed dendritic cells. Journal of Microbiology and Biotechnology 23(7):1023-1030
110. Quang-Tam Nguyen, Thu-Ha T. Nguyen, Seong-A Ju, Ye-Sol Lee, Seung Hyun Han, Sang-Chul Lee, Byoung S. Kwon, Rina Yu, Gyu Yeol Kim, Byung Ju Lee and Byung-Sam Kim (2013.06). CD137 on neutrophils plays dual roles in anti-bacterial responses against Gram-positive and Gram-negative bacteria infection. Infection and Immunity 81(6):2168-2177
109. Sora Han, Ae Lee Jeong, Sunyi Lee, Jeong Su Park, Kwang Dong Kim, Inpyo Choi, Suk Ran Yoon, Myung Sok Lee, Jong-Seok Lim, Seung Hyun Han, Do Young Yoon, Young Yang (2013.05). Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. Journal of Immunology 190(9):4877-4886
108. Jin-Kyung Lee, Yoon-Jung Park, Kee-Yeon Kum, Seung Hyun Han, Seok-Woo Chang, Blythe Kaufman, Jin Jiang, Qiang Zhu, Kamran E. Safavi, Larz S.W. Spangberg (2013.05). Antimicrobial efficacy of a human β-defensin-3 peptide against Enterococcus faecalis biofilm. International Endodontic Journal 46(5):406-412
107. Girak Kim, Mi Seon Jang, Young Min Son, Min Ji Seo, Sang Yun Ji, Seung Hyun Han, In Duk Jung, Yeong-Min Park, Hyun Jung Jung, Cheol-Heui Yun (2013.04). Curcumin inhibits CD4+ T cell activation, but augments CD69 expression and TGF-β1-mediated generation of regulatory T cells at late phase. PLoS ONE 8(4):e62300
106. Jung Eun Baik, Sun Woong Hong, Seulggie Choi, Jun Ho Jeon, Ok-Jin Park, Kun Cho, Deog-Gyu Seo, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han (2013.04). Alpha-amylase is a human salivary protein with affinity to lipopolysaccharide of Aggregatibacter actinomycetemcomitans. Molecular Oral Microbiology 28(2):142-153
105. Hyun-Shik Kim, Seok Woo Chang, Seung-Ho Baek, Seung Hyun Han, Yoon Lee, Qiang Zhu, Kee-Yeon Kum (2013.03). Antimicrobial effect of alexidine and chlorhexidine against Enterococcus faecalis infection. International Journal of Oral Science 5(1):26-31
104. Sun-Je Woo, Jintaek Im, Jun Ho Jeon, Seok-Seong Kang, Mee-Hee Lee, Cheol-Heui Yun, Eun-Yi Moon, Man Ki Song, Hong-Hee Kim, Seung Hyun Han (2013.03). Induction of BAFF expression by IFN-γ via JAK/STAT signaling pathways in human intestinal epithelial cells. Journal of Leukocyte Biology 93(3):363-368
103. Seok-Seong Kang, Hye Jin Kim, Mi Seon Jang, Sunjin Moon, Sang In Lee, Jun Ho Jeon, Jung Eun Baik, Ok-Jin Park, Young Min Son, Gi Rak Kim, Donghyun Joo, Heebal Kim, Jae Yong Han, Cheol-Heui Yun, Seung Hyun Han (2012.08). Gene expression profile of human peripheral blood mononuclear cells induced by Staphylococcus aureus lipoteichoic acid. International Immunopharmacology 13(4):454-460
102. Seok-Seong Kang, Jun Ho Jeon, Sun Je Woo, Jae Seung Yang, Kyoung Whun Kim, Cheol-Heui Yun, Seung Hyun Han (2012.07). IFN-γ renders human intestinal epithelial cells responsive to lipopolysaccharide of Vibrio cholerae by down-regulation of DMBT1. Comparative Immunology, Microbiology and Infectious Diseases 35(4):345-354
101. Jun Ho Jeon, Sun Kyung Kim, Jung Eun Baik, Seok-Seong Kang, Cheol-Heui Yun, Dae Kyun Chung, Seung Hyun Han (2012.07). Lipoteichoic acid of Staphylococcus aureus enhances IL-6 expression in activated human basophils. Comparative Immunology, Microbiology and Infectious Diseases 35(4):363-374
100. Hye-Yeon Lee, Sujin Hyung, Na Yeon Lee, Tae-Soon Yong, Seung Hyun Han, Soon-Jung Park (2012.04). Excretory-secretory products of Giardia lamblia induce IL-8 production in human colonic cells via activation of p38, ERK1/2, NF-κB, and AP-1. Parasite Immunology 34(4):183-198
99. Kyoung-Soon Jang, Jung Eun Baik, Seok-Seong Kang, Jun Ho Jeon, Seulggie Choi, Yung-Hun Yang, Byung-Gee Kim, Cheol-Heui Yun, Seung Hyun Han (2012.03). Identification of staphylococcal lipoteichoic acid-binding proteins in human serum by high-resolution LTQ-Orbitrap mass spectrometry. Molecular Immunology 50(3):177-183
98. Ji-Min Sun, Seong-Jun Kim, Geon-Woo Kim, Jin-Kyu Rhee, Nam Doo Kim, Heeyong Jung, Jungae Jeun, Seung-Hoon Lee, Seung Hyun Han, Chul Soo Shin, Jong-Won Oh (2012.01). Inhibition of hepatitis C virus replication by Monascus pigment derivatives that interfere with viral RNA polymerase activity and the mevalonate biosynthesis pathway. Journal of Antimicrobial Chemotherapy 67(1):49-58
97. Seok-Woo Chang, Seung-Ho Baek, Hyeong-Cheol Yang, Deok-Gyu Seo, Sung-Tae Hong, Seung Hyun Han, Yoon Lee, Yu Gu, Ho-Bum Kwon, Woocheol Lee, Kwang-Shik Bae, Kee-Yeon Kum (2011.12). Heavy metal analysis of ortho MTA and proRoot MTA. Journal of Endodontics 37(12):1673-1676
96. Hayoung Go, Christopher J. Moore, Minho Lee, Eunkyoung Shin, Che Ok Jeon, Chang-Jun Cha, Seung Hyun Han, Su-Jin Kim, Sang-Won Lee, Younghoon Lee, Nam-Chul Ha, Yong-Hak Kim, Stanley N. Cohen and Kangseok Lee (2011.12). Upregulation of RNase E activity by mutation of a site that uncompetitively interferes with RNA binding. RNA Biology 8(6):1022-1034
95. Sang-Mi Ryou, Mira Park, Jong-Myung Kim, Che Ok Jeon, Cheol-Hui Yun, Seung Hyun Han, Si Wouk Kim, Younghoon Lee, Sudeok Kim, Min Su Han, Jeehyeon Bae, Kangseok Lee (2011.11). Inhibition of xenograft tumor growth in mice by gold nanoparticle-assisted delivery of short hairpin RNAs against Mcl-1L. Journal of Biotechnology 156(2): 89-94
94. Na Yeon Lee, Hye-Yeon Lee, Kyu-Ho Lee, Seung Hyun Han, Soon-Jung Park (2011.10). Vibrio vulnificus IlpA induces MAPK-mediated cytokine production via TLR1/2 activation in THP-1 cells, a human monocytic cell line. Molecular Immunology 49(1-2):143-154
93. Dipika Sur, Suman Kanungo, Binod Sah, Byomkesh Manna, Mohammad Ali, Allison M. Paisley, Swapan K. Niyogi, Jin Kyung Park, Banawarilal Sarkar, Mahesh K Puri, Deok Ryun Kim, Jacqueline L. Deen, Jan Holmgren, Rodney Carbis, Raman Rao, Nguyen Thu Van, Seung Hyun Han, Stephen Attridge, Allan Donner, Nirmal K. Ganguly, Sujit K. Bhattacharya, G. Balakrish Nair, John Clemens, Anna Lena Lopez (2011.10). Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial. PLoS Neglected Tropical Diseases 5(10):e1289
92. Geun-Hee Lee, Jin-Mi Oh, Hyun-Sun Kim, Won-Kee Yoon, Kyu Yang Yi, Young Yang, Seung Hyun Han, Sunkyung Lee, Eun-Yi Moon (2011.10). KR33426, [2-(2,5-dichlorophenyl)-5- methyloxazol-4ylcarbonyl] guanidine, is a novel compound to be effective on mouse systemic lupus erythematosus. European Journal of Pharmacology 668(3):459-466
91. Seulggie Choi, Jung Eun Baik, Jun Ho Jeon, Kun Cho, Deog-Gyu Seo, Kee-Yeon Kum, Cheol-Heui Yun, Seung Hyun Han (2011.09). Identification of Porphyromonas gingivalis lipopolysaccharide-binding proteins in human saliva. Molecular Immunology 48:2207-2213
90. Seok-Seong Kang, Young Hee Ryu, Jung Eun Baik, Cheol-Heui Yun, Kangseok Lee, Dae Kyun Chung, Seung Hyun Han (2011.09). Lipoteichoic acid from Lactobacillus plantarum induces nitric oxide production in the presence of interferon-γ in murine macrophages. Molecular Immunology 48:2170-2177
89. Min Ji Seo, Gi Rak Kim, Woung Min Son, Deok-Chun Yang, Hyuk Chu, Tae Sun Min, In Duk Jung, Yeong-Min Park, Seung Hyun Han, Cheol-Heui Yun (2011.09). Interactions of dendritic cells with cancer cells and modulation of surface molecules affect functional properties of CD8+ T cells. Molecular Immunology 48:1744-1752
88. Kyoung-Whun Kim, Jintaek Im, Jun Ho Jeon, Hong-Gu Lee, Cheol-Heui Yun, Seung Hyun Han (2011.07). Staphylococcus aureus induces IL-1ß expression through the activation of MAP kinases and AP-1, CRE and NF-κB transcription factors in the bovine mammary gland epithelial cells. Comparative Immunology, Microbiology and Infectious Diseases 34(4):347-354
87. Kyoung-Soon Jang, Jung Eun Baik, Seung Hyun Han, Dae Kyun Chung, Byung-Gee Kim (2011.04). Multi-spectrometric analyses of lipoteichoic acids isolated from Lactobacillus plantarum. Biochemical and Biophysical Research Communications 407(4):823-830
86. Jung Eun Baik, Kyoung-Soon Jang, Seok-Seong Kang, Cheol-Heui Yun, Kangseok Lee, Byung-Gee Kim, Kee-Yeon Kum, Seung Hyun Han (2011.02). Calcium hydroxide inactivates lipoteichoic acid from Enterococcus faecalis through deacylation of the lipid moiety. Journal of Endodontics 37(2):191-196
85. Jun Ho Jeon, Sun Kyung Kim, Jintaek Im, Ki Bum Ahn, Jung Eun Baik, Ok-Jin Park, Cheol-Heui Yun, Seung Hyun Han (2011.02). Trp-P-1, a carcinogenic heterocyclic amine, inhibits lipopolysaccharide-induced maturation and activation of human dendritic cells. Cancer Letters 301(1):63-74
84. Young Sook Kim, Jun Ho Jeon, Jintaek Im, Seok-Seong Kang, Jung Nam Choi, Hyang Ran Ju, Cheol-Heui Yun, Chang Gue Son, Choong Hwan Lee, Seung Hyun Han (2011.01). Induction of intercellular adhesion molecule-1 by water-soluble components of Hericium erinaceum in human monocytes. Journal of Ethnopharmacology 133(2):874-880
83. Han Geun Kim, Seung Yeon Lee, Na Ra Kim, Hea Young Lee, Mi Yeon Ko, Bong Jun Jung, Chul Min Kim, Jung Min Lee, Jong Hwan Park, Seung Hyun Han, Dae Kyun Chung (2011.01). Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation. Molecular Immunology 48(4):382-391
82. Byoung-Shik Shim, Sung-Moo Park, Ji-Shan Quan, Dhananjay Jere, Hyuk Chu, Manki Song, Dong Wook Kim, Yong-Suk Jang, Moon-Sik Yang, Seung Hyun Han, Yong-Ho Park, Chong-Su Cho, Cheol-Heui Yun (2010.12). Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses. BMC Immunology 11:65
81. Woo-Seok Song, Sang-Mi Ryou, Hong-Man Kim, Che Ok Jeon, Jong-Myung Kim, Seung Hyun Han, Si Wouk Kim, Jin P. Szatkiewicz, Philip R. Cunningham, Kangseok Lee (2010.12). Functional investigation of residue G791 of Escherichia coli 16S rRNA: implication of initiation factor 1 in the restoration of P-site function. FEMS Microbiology Letters 313(2):141-147
80. Young Min Son, Sung Min Ahn, Gi Rak Kim, Yang Soo Moon, Sang Hoon Kim, Yeong-Min Park, Woon Kyu Lee, Tae Sun Min, Seung Hyun Han, Cheol-Heui Yun (2010.06). Resistin enhances the expansion of regulatory T cells through modulation of dendritic cells. BMC Immunology 11(1):33
79. Young Min Son, Chae Won Kwak, Yeo Jin Lee, Deok-Chun Yang, Byung-Chul Park, Woon Kyu Lee, Seung Hyun Han, Cheol-Heui Yun (2010.03). Ginsenoside Re enhances survival of human CD4+ T cells through regulation of autophagy. International Immunopharmacology 10(5):626-631
78. Young Suk Kim, Jintaek Im, Jung Nam Choi, Seok-Seong Kang, Yeo Jin Lee, Choong Hwan Lee, Cheol-Heui Yun, Chang Gue Son, Seung Hyun Han (2010.03). Induction of ICAM-1 by Armillariella mellea is mediated through generation of reactive oxygen species and JNK activation. Journal of Ethnopharmacology 128(1):198-205
77. Se-Hoon Sim, Ji-Hyun Yeom, Choy Shin, Woo-Seok Song, Eunkyoung Shin, Hong-Man Kim, Chang-Jun Cha, Seung Hyun Han, Nam-Chul Ha, Si Wouk Kim, Yoonsoo Hahn, Jeehyeon Bae, Kangseok Lee (2010.01). Escherichia coli RNase III activity is downregulated by osmotic stress: consequences for the degradation of bdm mRNA in biofilm formation. Molecular Microbiology 75(2):413-425
76. Jung-Min Eom, Min-Ji Seo, Ji-Young Baek, Hyuk Chu, Seung Hyun Han, Tae Sun Min, Chong-Su Cho, Cheol-Heui Yun (2010.01). Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. Biochemical and Biophysical Research Communications 391(1):903-908
75. Sun Kyung Kim, Chang Gue Son, Cheol-Heui Yun, Seung Hyun Han (2010.01). Hericium erinaceum induces maturation of dendritic cells derived from human peripheral blood monocytes. Phytotherapy Research 24(1):14-19
74. Ji Young Han, Jintaek Im, Jung Nam Choi, Choong Hwan Lee, Hye Jin Park, Dong Ki Park, Cheol-Heui Yun, Seung Hyun Han (2010.01). Induction of IL-8 expression by Cordyceps militaris grown on germinated soybeans through lipid rafts formation and signaling pathways via ERK and JNK in A549 cells. Journal of Ethnopharmacology 127(1):55-61
73. Jin Young Kang, Xuehua Nan, Mi Sun Jin, Suk-Jun Youn,Young Hee Ryu, Shinjee Mah, Seung Hyun Han, Hayyoung Lee, Sang-Gi Paik, Jie-Oh Lee (2009.12). Recognition of lipopeptide patterns by TLR2-TLR6 heterodimer. Immunity 31(6)
72. Jae Seung Yang, Seulggie Choi, David D. Kim, Seok-Seong Kang, Cheol-Heui Yun, Kangseok Lee, Seung Hyun Han (2009.12). A duplex vibriocidal assay to simultaneously measure bactericidal antibody titers against Vibrio cholerae O1 Inaba and Ogawa serotypes. Journal of Microbiological Methods 79(3):289-294
71. Jintaek Im, Jun Ho Jeon, Min Kyung Cho, Sang Su Woo, Seok-Seong Kang, Cheol-Heui Yun, Kangseok Lee, Dae Kyun Chung, Seung Hyun Han (2009.12). Induction of IL-8 expression by bacterial flagellin is mediated through lipid raft formation and intracellular TLR5 activation in A549 cells. Molecular Immunology 47(2-3):614-622
70. Suman Kanungo, Allison Paisley, Anna Lena Lopez, Mihir Bhattacharya, Byomkesh Manna, Deok Ryun Kim, Seung Hyun Han, Stephen Attridge, Rodney Carbis, Raman Rao, Jan Holmgren, John D. Clemens, Dipika Sur (2009.11). Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata India: A randomized, placebo-controlled trial. Vaccine 27(49):6887-6893
69. Jihyun Yang, Sang Su Woo, Young Hee Ryu, Cheol-Heui Yun, Min-Hee Cho, Gi-Eun Rhie, Bong-Su Kim, Hee-Bok Oh, Seung Hyun Han (2009.10). Bacillus anthracis lethal toxin attenuates lipoteichoic acid-induced maturation and activation of dendritic cells through a unique mechanism. Molecular Immunology 46(16):3261-3268
68. Jihyun Yang, Young Hee Ryu, Cheol-Heui Yun, Seung Hyun Han (2009.10). Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like receptor 2 with partial involvement of MyD88. Journal of Leukocyte Biology 86(4):823-831
67. Mi Seon Jang, Young Min Son, Gi Rak Kim, Yeo Jin Lee, Woon Kyu Lee, Seok Ho Cha, Seung Hyun Han, Cheol-Heui Yun (2009.09). Synergistic production of interleukin-23 by dendritic cells derived from cord blood in response to co-stimulation with LPS and IL-12. Journal of Leukocyte Biology 86:691-699
66. Raghu P. Kataru, Keehoon Jung, Cholsoon Jang, Hanseul Yang, Reto A. Schwendener, Jung Eun Baik, Seung Hyun Han, Kari Alitalo, Gou Young Koh (2009.05). Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood 113(22):5650-9
65. Hong-Man Kim, Sang-Mi Ryou, Woo-Seok Song, Se-Hoon Sim, Chang-Jun Cha, Seung Hyun Han, Nam-Chul Ha, Philip R. Cunningham, Jae-Hong Kim, Jeehyeon Bae, Kangseok Lee (2009.04). Genetic analysis of the invariant residue G791 in Escherichia 1 coli 16S rRNA implicates RelA in ribosome function. Journal of Bacteriology 191(7):2042-2050
64. Jae-Hong Kim, Seongmin Yoon, Miae Won, Se-Hoon Sim, Jeong-Jae Ko, Seung Hyun Han, Kyung-Ah Lee, Kangseok Lee, Jeehyeon Bae (2009.02). HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cellular Physiology and Biochemistry 23(1-3):43-52
63. Jin-Kyung Lee, Jung Eun Baik, Cheol-Heui Yun, Kangseok Lee, Seung Hyun Han, Woo Cheol Lee, Yoon Lee, Won-Jun Son, Seung-Ho Baek, Kwang-Shik Bae, Kee-Yeon Kum (2009.02). Chlorhexidine gluconate attenuates the ability of lipoteichoic acid from Enterococcus faecalis to stimulate Toll-like receptor 2. Journal of Endodontics 35(2):212-215
62. Jintaek Im, Hyung Shim Choi, Sun Kyung Kim, Sang Su Woo, Young Hee Ryu, Seok-Seong Kang, Cheol-Heui Yun, Seung Hyun Han (2009.02). A food-born heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), suppresses tumor necrosis factor-α expression in lipoteichoic acid-stimulated RAW 264.7 cells. Cancer Letters 274(1):109-117
61. Young Hee Ryu, Jung Eun Baik, Jae Seung Yang, Seok-Seong Kang, Jintaek Im, Cheol-Heui Yun, Dong Wook Kim, Kangseok Lee, Dae Kyun Chung, Hyang Ran Ju, Seung Hyun Han (2009.01). Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids. International Immunopharmacology 9(1):127-133
60. Young Min Son, Sung Min Ahn, Mi Seon Jang, Yang Soo Moon, Sang Hoon Kim, Kwang-Keun Cho, Seung Hyun Han, Cheol-Heui Yun (2008.11). Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus. Biochemical and Biophysical Research Communications 376(3):599-604
59. Jung Eun Baik, Kee-Yeon Kum, Cheol-Heui Yun, Jin-Kyung Lee, Kang seok Lee, Kack Kyun Kim, Seung Hyun Han (2008.11). Calcium hydroxide inactivates lipoteichoic acid from Enterococcus faecalis. Journal of Endodontics 34(11):1355-1359
58. Sun Kyung Kim, Jintaek Im, Cheol-Heui Yun, Jin Young Son, Chang Gue Son, Dong Ki Park, Seung Hyun Han (2008.09). Armillariella mellea induces maturation of human dendritic cells without induction of cytokine expression. Journal of Ethnopharmacology 119(1):153-159
57. Eunkyoung Shin, Hayoung Go, Ji-Hyun Yeom, Miae Won, Jeehyeon Bae, Seung Hyun Han, Kook Han, Younghoon Lee, Nam-Chul Ha, Christopher J. Moore, Bjorn Sohlberg, Stanley N. Cohen and Kangseok Lee (2008.08). Identification of amino acid residues in the catalytic domain of RNase E essential for survival of Escherichia coli: Funtional analysis of DNase I subdomain. Genetics 179(4):1871-1879
56. Jung Eun Baik, Young Hee Ryu, Ji Young Han, Jintaek Im, Kee-Yeon Kum, Cheol-Heui Yun, Kangseok Lee, Seung Hyun Hann (2008.8). Lipoteichoic acid partially contributes to the inflammatory responses to Enterococcus faecalis. Journal of Endodontics 34(8):975-982
55. Ji-Hyun Yeom, Hayoung Go, Eunkyoung Shin, Hyun-Lee Kim, Seung Hyun Han, Christopher Moore, Jeehyeon Bae, Kangseok Lee (2008.08). Inhibitory effects of RraA and RraB on RNase E-related enzymes imply conserved functions in the regulated enzymatic cleavage of RNA. FEMS Microbiology Letters 285(1):10-15
54. Yoon Lee, Seung Hyun Han, Jin-Kyung Lee, Kee-Yeon Kum (2008.07). Antimicrobial efficacy of a polymeric chlorhexidine-controlled release device using in vitro model of Enterococcus faecalis dentinal tubule infection. Journal of Endodontics 34(7):855-858
53. Dilip Mahalanabis, Anna Lena Lopez, Dipika Sur, Jacqueline Deen, Byomkesh Manna, Suman Kanungo, Lorenz von Seidlein, Rodney Carbis, Seung Hyun Han, Seong Hye Shin, Stephen Attridge, Raman Rao, Jan Holmgren, John Clemens, Sujit K Bhattacharya (2008.06). A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India. PLoS ONE 3(6):e2323 1-7
52. Dong Wook Kim, Hyuk Chu, Dong Hyun Joo, Mi-Sun Jang, Jin Huk Choi, Sung-Moo Park, Yun-Jae Choi, Seung Hyun Han, Cheol-Heui Yun (2008.06). OspF directly attenuates the activity of extracellular signal-regulated kinase during invasion by Shigella flexneri in human dendritic cells. Molecular Immunology 45(11):3295-3301
51. Eun-Yi Moon, Jong Soon Kang, Seung Hyun Han, Kyu-Hwan Yang, Suhkneung Pyo, Mi-Young Lee, Hyung-Kyu Lee, Dae-Yeul Yu (2008.06). Differential role of peroxiredoxin II (PrxII) on the expression of toll-like receptor 4 (TLR4) and B cell activating factor (BAFF) in ovalbumin (OVA)-induced mouse asthma. International Immunopharmacology 8(6):935-944
50. Jin Huk Choi, Woon Kyu Lee, Seung Hyun Han, Seckho Ha, Sung Min Ahn, Jae Seong Kang, Yun Jaie Choi, Cheol-Heui Yun (2008.06). Identification and characterization of nonapeptide targeting a human B cell lymphoma, Raji. International Immunopharmacology 8(6):852-858
49. Jun Ho Jeon, Kun-yong Kim, Jae Hyeong Kim, Ahmi Baek, Hyungin Cho, Young Ho Lee, Jong Wan Kim, Dohee Kim, Seung Hyun Han, Jong-Seok Lim, Keun il Kim, Do Young Yoon, Soohyun Kim, Goo Taeg Oh, Eunjoon Kim, Young Yang (2008.05). A novel adipokine CTRP1 stimulates aldosterone production. FASEB Journal 22(5):1502-1511
48. Jintaek Im, Seok-Seong Kang, Jae Seung Yang, Cheol-Heui Yun, Young Yang, Seung Hyun Han (2008.03). 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) attenuates LPS-induced IL-8 expression by decreasing mRNA stability in THP-1 cells. Toxicology Letters 177(2):108-115
47. In Su Cheon, Sang Su Woo, Seok-Seong Kang, Jintaek Im, Cheol-Heui Yun, Dae Kyun Chung, Dong Ki Park, Seung Hyun Han (2008.03). Peptidoglycan-mediated IL-8 expression in human alveolar type II epithelial cells requires lipid raft formation and MAPK activation. Molecular Immunology 45(6):1665-1673
46. Han Geun Kim, Na-Ra Kim, Min Geun Gim, Jung Min Lee, Seung Yeon Lee, Mi Yeon Ko, Joo Yun Kim, Seung Hyun Han, Dae Kyun Chung (2008.02). Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice. Journal of Immunology 180(4):2553-2561
45. Jang Woo Shin, Jin Young Son, Jong Koo Kang, Seung Hyun Han, Chong Kwan Cho, Chang Gue Son (2008.01). Trichosanthes kirilowii tuber extract induces G2/M phase arrest via inhibition of tubulin polymerization in HepG2 Cells. Journal of Ethnopharmacology 115(2):209-216
44. Suk Ji, Youngsook Kim, Jieun Shin, Byung-Moo Min, Seung Hyun Han, Youngnim Choi (2007.12). Innate immune responses of gingival epithelial cells to non-periodontopathic and periodontopathic bacteria. Journal of Periodontal Research 42(6):503-510
43. Jae Seung Yang, Hye Jin Kim, Cheol-Heui Yun, Seok-Seong Kang, Jintaek Im, Hak Sung Kim, Seung Hyun Han (2007.11). A semi-automated vibriocidal assay for improved measurement of cholera vaccine-induced immune responses. Journal of Microbiological Methods 71(2):141-146
42. Seok-Seong Kang, Sang Su Woo, Jintaek Im, Jae Seung Yang, Cheol-Heui Yun, Hyang Ran Ju, Chang Gue Son, Eun-Yi Moon, Seung Hyun Han (2007.11). Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-kB and AP-1 in PMA-differentiated THP-1 cells. International Immunopharmacology 7(11):1488-1495
41. Cheol-Heui Yun, Jae Seung Yang, Seok-Seong Kang, Young Yang, Jung Hyo Cho, Chang Gue Son, Seung Hyun Han (2007.09). NF-kB signaling pathway, not IFN-beta/STAT1, is responsible for the selenium suppression of LPS-induced nitric oxide production. International Immunopharmacology 7(9):1192-1198
40. Myung Hyun Yim, Jang Woo Shin, Jin Young Son, Se Mi Oh, Seung Hyun Han, Jung Hyo Cho, Chong Kwan Cho, Hwa Seung Yoo, Yeon Weol Lee, Chang Gue Son (2007.06). Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes. Acta Pharmacologica Sinica 28(6): 901-907
39. Hye Jin Kim, Jae Seung Yang, Sang Su Woo, Sun Kyung Kim, Cheol-Heui Yun, Kack Kyun Kim, Seung Hyun Han (2007.04). Lipoteichoic acid and muramyl dipeptide synergistically induce maturation of human dendritic cells and concurrent expression of pro-inflammatory cytokines. Journal of Leukocyte Biology 81(4):983-989
38. Han Geun Kim, Min Geun Gim, Joo Yun Kim, Hyun Jin Hwang, Min Seok Ham, Jung Min Lee, Thomas Hartung, Jung Woo Park, Seung Hyun Han, Dae Kyun Chung (2007.03). Lipoteichoic acid from Lactobacillus plantarum elicits both the production of Interleukin-23p19 and suppression of pathogen-mediated Interleukin-10 in THP-1 cells. FEMS Immunology and Medical Microbiology 49(2):205-214
37. Dang Duc Anh, Do Gia Canh, Anna Lena Lopez, Vu Dinh Thiem, Phan Thi Long, Nguyen Hong Son, Jacqueline Deen, Lorenz von Seidlein, Rodney Carbis, Seung Hyun Han, Seong Hye Shin, Stephen Attridge, Jan Holmgren, John Clemens (2007.01). Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults. Vaccine 25(6):1149-1155
36. Woo Jin Choi, Jang Woo Shin, Jin Young Son, Dong Seok Seo, Hark Soo Park, Seung Hyun Han, Ha Jung Sung, Jung Hyo Cho, Chong Kwan Cho, Hwa Seung Yoo, Yeon Weol Lee, Chang Gue Son (2006.12). Toxicological study of the hepatotherapeutic herbal formula, CGX, in beagle dogs. World Journal of Gastroenterology 12(46):7497-7502
35. Jang Woo Shin, Jin Young Son, Se Mi Oh, Seung Hyun Han, Jing Hua Wang, Jung Hyo Cho, Chong Kwan Cho, Hwa Seung Yoo, Yeon Weol Lee, Myong Min Lee, Xia Ping Hu, Chang Gue Son (2006.10). An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World Journal of Gastroenterology 12(38):6142-6148
34. Chang Gue Son, Jang Woo Shin, Jung Hyo Cho, Chong Kwan Cho, Cheol-Heui Yun, Wantae Chung, Seung Hyun Han (2006.08). Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum. International Immunopharmacology 6(8):1363-1369
33. Chang Gue Son, Jang Woo Shin, Jung Hyo Cho, Chong Kwan Cho, Cheol-Heui Yun, Seung Hyun Han (2006.08). Induction of murine interleukin-1 beta expression by water-soluble components from Hericium erinaceum. Acta Pharmacologica Sinica 27(8):1058-1064
32. Kun-yong Kim, Hwa Young Kim, Jae Hyeong Kim, Chul-Ho Lee, Do-Hyung Kim, Young Ho Lee, Seung Hyun Han, Jong-Seok Lim, Dae Ho Cho, Myeong-Sok Lee, Sukjoon Yoon, Keun Il km, Do-Yong Yoon, Young Yang (2006.07). Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue. FEBS Letters 580(16) :3953-3960
31. Cheol-Heui Yun, Dae Kyun Chung, Kristopher Yoon, Seung Hyun Han (2006.06). Involvement of reactive oxygen species in the immunosuppressive effect of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a food-born carcinogenic heterocyclic amine. Toxicology Letters 164(1):37-43
30. Kun-yong Kim, Jae Kwang Kim, Seung Hyun Han, Jong-Seok Lim, Keun Il Kim, Dae Ho Cho, Myeong-Sok Lee, Jeong-Hyung Lee, Do-Young Yoon, Suk Ran Yoon, Jin Woong Chung, Inpyo Choi, Eunjoon Kim, Young Yang (2006.05). Adiponectin is a negative regulator of natural killer cell cytotoxicity Journal of Immunology 176(10):5958-5964
29. Jae Seung Yang, Hye Jin Kim, Young Hee Ryu, Cheol-Heui Yun, Dae Kyun Chung, Seung Hyun Han (2006.03). Endotoxin contamination in commercially-available pokeweed mitogen contributes to the activation of murine macrophages and human dendritic cell maturation. Clinical and Vaccine Immunology 13(3):309-313
28. Cheol-Heui Yun, Young Jin Jeon, Young Yang, Hyang Ran Ju, Seung Hyun Han (2006.02). Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells. International Immunopharmacology 6(2):252-259
27. Cheol-Heui Yun, Uhee Jung, Chang Gue Son, Hyang Ran Ju, Seung Hyun Han (2006.02). 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a food-born carcinogenic heterocyclic amine, promotes nitric oxide production in murine macrophages. Toxicology Letters 161:18-26
26. Cheol-Heui Yun, Chang Gue Son, Uhee Jung, Seung Hyun Han (2006.01). Immunosuppressive effect of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through the inhibition of T-lymphocyte proliferation and IL-2 production. Toxicology 217:31-38
25. Seung Hyun Han, Je Hak Kim, Ho Seong Seo, Michael H. Martin, Gook-Hyun Chung, Suzanne M. Michalek, Moon H. Nahm (2006.01). Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2. Journal of Immunology 176:573-579
24. Cheol-Heui Yun, Chang Gue Son, Dae Kyun Chung, Seung Hyun Han (2005.12). Chlorophyllin attenuates IFN-gamma in lipopolysaccharide-stimulated murine splenic mononuclear cells via suppressing IL-12 production. International Immunopharmacology 5(13-14):1926-1935
23. Hyuk Chu, Seungha Kang, Seckho Ha, Kwangkeun Cho, Sung-moo Park, Kyung-ho Han, Sang Kee Kang, HongGu Lee, Seung Hyun Han, Cheol H. Yun, Yunjaie Choi. (2005.11). Lactobacillus acidophilus expressing recombinant K99 adhesive fimbriae has an inhibitory effect on adhesion of enterotoxigenic Escherichia coli. Microbiology and Immunology 47(11):941-948
22. Je Hak Kim, Hoseong Seo, Seung Hyun Han, Jisheng Lin, Moon-Kook Park , Uffe B. S. Sorensen, Moon H. Nahm (2005.02). Monoacyl lipoteichoic acid from pneumococci stimulates human cells but not mouse cells. Infection and Immunity 73(2):834-840
21. Seung Hyun Han, Je Hak Kim, Michael H. Martin, Suzanne M. Michalek, Moon H. Nahm (2003.10). Pneumococcal lipoteichoic acid (LTA) is not potent as staphylococcal LTA in stimulating TLR2. Infection and Immunity 71(10):5541-5548
20. Seung Hyun Han, Jun Ho Jeon, Hyang Ran Ju, Uhee Jung, Kun Young Kim, Hyang Sook Yoo, Young Ho Lee, Kyu Sang Song, Ho Myeung Hwang, Yoon Sook Na, Young Yang, Kee Nyung Lee, Inpyo Choi (2003.06). VDUP1 upregulated by TGF-beta1 and 1,25-dihydroxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 22(26):4035-4046
19. Hyunkeun Song, Daeho Cho, Jun Ho Jeon, Seung Hyun Han, Dae Young Hur, Young Sang Kim, Inpyo Choi (2003.05). Vitamin D3 up-regulating protein 1 (VDUP1) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of Fas ligand and reactive oxygen species. Immunology Letters 86(3):235-247
18. Chang Gue Son, Woo Jin Choi, Jang Woo Shin, Seung Hyun Han, Jung Hyo Cho, Kee Cheol Song, Chong Kwan Cho (2003.02). Effects of Gamichunggantang on hyperlipidemia. Acta Pharmacologica Sinica 24(2):133-139
17. Chang Gue Son, Seung Hyun Han, Jung Hyo Cho, Jang Woo Shin, Chong Kwan Cho, Yeon Weol Lee, Chong Kwan Cho (2003.02). Induction of hemopoiesis by Saenghyuldan, a mixture of Ginseng Radix, Paeoniae Radix Alba, and Hominis Placenta extracts. Acta Pharmacologica Sinica 24(2):120-126
16. Jong Soon Kang, Young Jin Jeon, Hwan Mook Kim, Seung Hyun Han, Kyu-Hwan Yang (2002.07). Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. Journal of Pharmacology and Experimental Therapeutics 302(1):138-144
15. Young Yang, Seung Hyun Han, Hyun Kim, Changmee Kim, Kun-yong Kim, Sun Mi Shin, Inpyo Choi, Kwang Ho Pyun (2002.06). IL-12 p40 gene expression is induced in LPS-activated pituitary glad in vivo. Neuroendocrinology 75(6):347-357
14. Hyung Sik Kang, Min Ju Lee, Hyunkeun Song, Seung Hyun Han, Yong Man Kim, Joo Young Im, Inpyo Choi (2001.06). Molecular identification of IgE-dependent histamine releasing factor as a B cell growth factor. Journal of Immunology 166(11):6545-6554
13. Yong Man Kim, Joo Young Im, Seung Hyun Han, Hyung Sik Kang, Inpyo Choi (2000.09). IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and ativator protein-1 elements in Macrophages. Journal of Immunology 165(6):3198-3205
12. Eunsung Junn, Kee Nyung Lee, Hyang Ran Ju, Seung Hyun Han, Joo Young Im, Hyung Sik Kang, Tae Ho Lee, Yun Soo Bae, Kwon Soo Ha, Zee Won Lee, Sue Goo Rhee, Inpyo Choi (2000.08). Requirement of hydrogen peroxide generation in TGF-beta1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta1-induced IL-6 expression. Journal of Immunology 165(4):2190-2197
11. Yong Woo Lee, Seung Hyun Han, Michael Lee, Kyu-Hwan Yang, Hwan Mook Kim, Young Jin Jeon (2000.08). 2-Amino-3-methylimidazo[4,5-f]quinoline inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells by blocking p38 kinase activation. Cancer Letters 156(2):133-139
10. Young Jin Jeon, Seung Hyun Han, Yong Woo Lee, Michael Lee, Kyu-Hwan Yang, Hwan Mook Kim (2000.07). Dexamethasone inhibits IL-1beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-κB/Rel and AP-1 activation. Immunopharmacology 48(2):173-183
9. Kyung-Joo Cho, Seung Hyun Han, Bu Yeo Kim, Seong-Gu Hwang, Kwang-Kyun Park, Kyu-Hwan Yang, An-Sik Chung (2000.07). Chlorophyllin suppression of lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Toxicology and Applied Pharmacology 166(2):120-127
8. Eunsung Junn, Seung Hyun Han, Joo Young Im, Young Yang, Eun Wie Cho, Hong Duck Um, Do Kyun Kim, Kang Woo Lee, Pyung Lim Han, Sue Goo Rhee, Inpyo Choi (2000.06). Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. Journal of Immunology 164(12):6287-6295
7. Seung Hyun Han, Youn Jin Jeon, Sung Su Yea, Kyu-Hwan Yang (1999.07). Suppression of the interleukin-2 gene expression by aflatoxin B 1 is mediated through the down-regulation of the NF-AT and AP-1 transcription factors. Toxicology Letters 108(1):1-10
6. Youn Jin Jeon, Seung Hyun Han, Jong Soon Kang, Kyu-Hwan Yang (1999.02). Acetyl aminofluorene inhibits nitric oxide production in LPS-stimulated RAW 264.7 cells by blocking NF-kB/Rel activation. Toxicology Letters 104(3):195-202
5. Seung Hyun Han, Sung Su Yea, Young Jin Jeon, Kyu-Hwan Yang, Norbert E. Kaminski (1998.12). Transforming growth factor-beta 1 (TGF-ß1) promotes IL-2 mRNA expression through the up-regulation of NF-κB, AP-1 and NF-AT in EL4 cells. Journal of Pharmacology and Experimental Therapeutics 287(3):1105-1112
4. Yong Woo Lee, Seung Hyun Han, Jae Hong Suh, Youn Jin Jeon, Kyu-Hwan Yang (1998.12). Down-regulation of protein kinase C: a potential mechanism for 2-amino-3-methylimidazo[ 4,5-']quinoline-mediated immunosuppression. Toxicology Letters 102-103:79-83
3. Young Jin Jeon, Seung Hyun Han, Yong Woo Lee, Sung Su Yea, Kyu-Hwan Yang (1998.07). Inhibition of NF-kB/Rel nuclear translocation by dexamethasone: Mechanism for the Inhibition of iNOS gene expression. Biochemistry and Molecular Biology International 45(3):435-441
2. Yanli Ouyang, Seong Gu Hwang, Seung Hyun Han, Norbert E. Kaminski (1998.04). Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells. Molecular Pharmacology 53(4):676-683
1. Young Jin Jeon, Seung Hyun Han, Kyu-Hwan Yang, Norbert E. Kaminski (1997.05). Induction of liver-associated transforming growth factor ß1 (TGF-ß1) mRNA expression by carbon tetrachloride leads to the inhibition of helper 2 cell-associated lymphokines. Toxicology and Applied Pharmacology 144(1):27-35