이승복 Seung-bok Lee   교수 / Ph.D.
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· Major : 두개악안면세포 및 발생생물학
· E-mail : seunglee@snu.ac.kr
· Tel : 02-740-8737
· Laboratory : 발생유전학 연구실
Current Research Interests

동물의 배아 발생과정에서 대부분 형성되는 신경시냅스는 정적으로 유지되는 것이 아니라 발생신호나 신경활성에 의하여 매우 역동적으로 기능과 구조를 변화시키는 가소성을 나타낸다. 이러한 시냅스 가소성은 신경회로의 refinement를 위하여 필수적이며, 또한 성체에서 일어나는 학습과 기억의 가장 핵심적인 기전으로 작용한다. 한편, 시냅스는 퇴행성 신경질환이 진행되는 과정에서 기능적/구조적으로 약화되는 변화를 보인다. 본 연구진은 초파리 신경근육이음부 (Neuromuscular Junction)과 마우스의 해마 (Hippocampus)에 존재하는 glutamatergic 시냅스를 모델로 이용하여, 시냅스 가소성 및 퇴행성 신경질환이 유발되는 기전을 연구를 진행하고 있다.
 

Research Methodology

1. Retrograde (Postsynaptic to Presynaptic) Signaling에 의한 시냅스 가소성의 조절. 2. Endocytic/Exocytic Protein에 의한 시냅스 기능 및 구조의 조절. 3. Hereditary Spastic Paraplegia (유전경직하반신 마비)의 병리기전: Atlastin & Spartin.

Publication / Patent

Minyeop Nahm, Min-Jung Lee, William Parkinson, Mihye Lee, Haeran Kim, Yoon-Jung Kim, Sungdae Kim, Yi Sul Cho, Byung-Moo Min, Yong Chul Bae, Kendal Broadie, and Seungbok Lee, "Spartin Regulates Synaptic Growth and Neuronal Survival by Inhibiting BMP-Mediated Microtubule Stabilization," in Neuron, In press. Dani N, Nahm M, Lee S, Broadie K., "A Targeted Glycan-Related Gene Screen Reveals Heparan Sulfate Proteoglycan Sulfation Regulates WNT and BMP Trans-Synaptic Signaling.," in PLoS Genetics, Vol. 8, No. 11, pp. e1003031, Nov., 2012. Lee JH, Kim HN, Kim KO, Jin WJ, Lee S, Kim HH, Ha H, Lee ZH., "CXCL10 promotes osteolytic bone metastasis by enhancing cancer outgrowth and osteoclastogenesis.," in Cancer Research, Vol. 72, No. 13, pp. 3175-3186, Jul., 2012. Seo SY, Min SK, Bae HK, Roh D, Kang HK, Roh S, Lee S, Chun GS, Chung DJ, Min BM., "A laminin-2-derived peptide promotes early-stage peripheral nerve regeneration in a dual-component artificial nerve graft.," in Journal of Tissue Engineering and Regenerative Medicine, Mar., 2012. Song MG, Kang B, Jeon JY, Chang J, Lee S, Min CK, Youn H, Choi EY., "In vivo imaging of differences in early donor cell proliferation in graft-versus-host disease hosts with different pre-conditioning doses," in Molecules and Cells, Vol. 33, No. 1, pp. 79-86, Jan., 2012. Lee, S., Kim, S., Nahm, M,. Kim, E., Kim, T.-I., Yoon, JH. Lee, S., "The phosphoinositide phosphatase Sac1 is required for midline axon guidance.," in Molecules and Cells, Vol. 32, No. 5, pp. 477-482, Nov., 2011. Hong I, Kim J, Lee J, Park S, Song B, Kim J, An B, Park K, Lee HW, Lee S, Kim K, Park SH, Eom KD, Lee S, Choi S., "Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation.," in PLoS ONE, Vol. 6, No. 9, pp. e24260, Sept., 2011. Nahm, M., Lee, S., "Characterization of the Rho GTPase-Activating Protein RhoGAP68F.," in Experimental Neurobiology, Vol. 20, No. 1, pp. 29-34, Mar., 2011 Nahm M, Long AA, Paik SK, Kim S, Bae YC, Broadie K, Lee S., "The Cdc42-selective GAP Rich regulates postsynaptic development and retrograde BMP transsynaptic signaling," in J Cell Biol, Vol. 191, No. 3, pp. 661–675, Nov., 2010. Nahm M*, Kim S*, Paik SK, Lee M, Lee S, Lee ZH, Kim J, Lee D, Bae YC, Lee S. dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal.J Neurosci. 30(24)8138-50 (2010) Lee M, Paik SK, Lee MJ, Kim YJ, Kim S, Nahm M, Oh SJ, Kim HM, Yim J, Lee CJ, Bae YC, Lee S. Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development. Dev. Biol. 330(2):250-262 (2009) . Lee Y, Paik D, Bang S, Kang J, Chun B, Lee S, Bae E, Chung J, Kim J. Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila. Neurobiol. Aging 29(1):84-94 (2008). Lee S, Nahm M, Lee M, Kwon M, Kim E, Zadeh AD, Cao H, Kim HJ, Lee ZH, Oh SB, Yim J, Kolodziej PA, Lee S. The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. Development 134(9):1767-1777 (2007). Nahm M, Lee M, Baek S-H, Yoon J-H, Kim H-H, Lee ZH, Lee S. Drosophila RhoGEF4 encodes a novel RhoA-specific guanine exchange factor that is highly expressed in the embryonic central nervous system. Gene 384:139-144 (2006).