김명진 Myung-Jin Kim   교수 / D.D.S., Ph.D.
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· Major : 구강종양외과학, 주걱턱 및 턱얼굴기형, 임플란트 재건외과학
· E-mail : myungkim@snu.ac.kr
· Tel : 02-2072-2632
· Laboratory : 구강악안면외과학연구실
Current Research Interests

구강악안면영역은 입안 뿐 아니라 턱,얼굴 부위를 총칭하는 것으로, 본 교실에서 구강악안면영역에서 발생하는 암을 비롯한 각종 종양질환, 선천성 후천성기형,  인공치아임프란트재건등  에 대하여 임상연구하고 그 치료법 개발하고 있습니다.

1. 구강암 연구(Oral & Maxillofacial Cancer Research)
구강 및 악안면부위에 발생하는 암의 진단, 예방, 치료, 및 예후 분석 및 분자생물학적인 방법을 이용한 연구를 시행하고 있음. 암 표지자 연구,   병기별, 부위별 치료전략,  구강 편평세포암종에 효과적인 항암제의 개발 ,  임파절로의 전이가 암종의 예후에 미치는 영향 등

2. 악안면 기형(Dentofacial deformity)에 대한 연구
하악전돌증(주걱턱), 안면비대칭, 구순구개열 등 선천적, 후천적기형에 대한 진단 및 치료법을 개발하고 있음. 3차원 영상 및 모델을 이용하여 3차원적인 악안면 기형의 분석과 컴퓨터 시뮬레이션 및 네비게이션 수술의 개발

3. 인공치아 임플란트 재건술
악골의 치아 결손 시 치조골 및 악골의 재건과 함께 인공치아 식립을 통한 악구강기능의 회복

4. 골신장술(Distraction osteogenesis)
치조골 퇴축, 외상 등으로 인한 골결손, 반안면왜소증의 치료에 조직 이식 이외에 골 및 연조직의 신장을 이용하여 결손부를 회복하는 방법.
 

Publication / Patent

1. JH Lee, MJ Kim, JW Kim : Mandibular reconstruction with free vascularized fibular flap. J. Cranio Max-fac. Surg. 23:20-26, 1995. 2. J-H. Lee, Y-Y. Kim. B-M. S대. S-H Baek, J-Y Choi, P-H Choung. M-J Kim ; Extra-articular pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature. Int. J. of Oral Max.fac. Surg. 29:408-415, 2000 3. Hoon Myoung, Seong-Doo Hong, Young-Youn Kim, Sam-Pyo Hong, Myung-Jin Kim : Evaluation of the anti-tumor and anti-angiogenic effect of paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma. Cancer Letters 163-191, 200 Elsevier Sci Publ Ireland Ltd, 2001 4. Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, Lee JH, Choi JY, Seo BM, Kim MJ : Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 91(3):328-333, Mosby-Year Book Inc, 2001 5. Kim MJ, Lee JH, Choi JY, Kang N, Lee JH, Choi WJ : two stage reconstruction of bilateral alveolar cleft using Y-shaped anterior-based tongue flap and iliac bone graft. Cleft Palate-Craniofacial Journal, 38(5):432-437, Decker Periodicals Inc, 2001 6. Jin-Young Choi, Kyung-Gyun Hwang, Seung-Hak Baek, Jong-Ho Lee, Tae-Woo Kim, Myung-Jin Kim, Young-II Chang: Original sagittal split osteotomy revisited for mandibular distraction. Journal of Cranio-Maxillo-Facial Surgery, 29(3):165-173, Elservier Science, 2001 7. Cho YS, Kim MJ: Expression of multidrug resistance genes in oral squamous cell carcinomas. Oral Oncology, 37(1):652-659, 2001 8. Myoung H, Kim YY, Heo MS, Lee SS, Choi SC, Kim MJ: Comparative radiologic study of bone density and cortical thicknes of donor bone used in mandibular reconstruction. Oral Surg Ora Med Oral Pathol Oral Radio Endod, 92:23-29, American academy of Oral & Maxillofacial Radiology, 2001 9. M J Kim, S K Kim, Y W Park, S G Kim: Positional stability following intentional posterior ostectomy of the distal segment in bilateral sagittal split ramus osteotomy for correction of mandibular prognathism. Journal of Cranio-Maxillofacial Surgery, 30(1):35-40 Churchill Livingstone, 2002 10. J.-Y. Choi, J.-H. Choi, N.-K. Kim, Y. Kim, J.-K. Lee, M.-K. Kim, J.-H. Lee, M.-J. Kim: Analysis of errors in medical rapid prototyping models. International Journal of Oral and Maxillofacial Surgery, 31(1):23-32, Churchill Livingstone, 2002 11. Hoon Myoung, Myung-Jin Kim, Seong-Doo Hong, Jae-Il Lee, Chang-Yun Lim, Sam-Pyo Hong : Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma, Cancer Letter, 185:201-209, Elsevier, 2002 12. Hoon Myoung, Sam-Pyo Hong, Pil-Young Yun, Jong-Ho Lee, Myung-Jin Kim : The anti-cancer effect of Genistein in oral squamous cell carcinoma with respect to the angiogenesis and in vitro Invasion, Japan. J of Cancer Reserch (Cancer Science), 94(2):215-220, Japanese Cancer Association, 2003 13. Ahn KM, Kim MJ, Lee JH : Prelaminated fasciomucosal flap using tongue mucosa in a rat model. J Reconstr Microsurg. 2003 Apr;19(3):195-201 14. JH Lee, MJ Kim, WS Choi, PY Yoon, KM Ahn, H Myung, SJ Hwang, BM S대, JYChoi, PH Choung, SM Kim : Concomitant reconstruction of mandibular basal and alveolar bone with a free fibular flap. Int. J. Oral Maxillofac. Surg., 33: 150-156, 2004 15. Jeong-Keun Lee, Myung Jin Kim, San Pyo Hong, Seong-Doo Hong : Inactivation Patterns of p16/INK4A in Oral Squamous Cell Carcinomas. Experimental and molecular medicine 32(2):165-171, April 30th, 2004 16. J.Y. Choi, C.G. Min, H. Myoung, D.J. Hwang, M.J. Kim, J.H. Lee: Acquired syngnathia. British Journal of Oran & Maxillofacial Surgery, 42(5):448~450, Oct 2004. 17. Lim J, Kim JH, Paeng JY, Kim MJ, Hong SD, Lee JI, Hong SP. Prognostic value of activated Akt expression in oral squamous cell carcinoma. J Clin Pathol 2005;58(11):1099-1205 18. Kim MJ, Lim KY, Kim JW, Nam IW, Lee JH, Myoung H. Stage and mRNA expression of survivin in lymph node as prognostic indicators in patients with oral squamous cell carcinoma. Cancer Lett. 2005, 224(2):253-261 19. Choi KK, Kim MJ, Yun PY, Lee JH, Moon HS, Lee TR, Myoung H. Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults. Oral Oncol. 2006 Feb;42(2):208-17. 20. Baek SH, Kim TK, Kim MJ. Is there any difference in the condylar position and angulation after asymmetric mandibular setback? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Feb;101(2):155-63. 21. Kang-Min Ahn, Jong-Ho Lee, Soon-Jung Hwang, Pill-Hoon Choung, Myung-Jin Kim, Hee-Jung Park, Jung-Keug Park, and Jeong-Won Jahng. Artificial Organs, 2006, 30(6):409-421 22. Myoung H, Kim MJ, Lee JH, Ok YJ, Paeng JY, Yun PY. Correlation of proliferative markers (Ki-67 and PCNA) with survival and lymph node metastasis in oral squamous cell carcinoma: a clinical and histopathological analysis of 113 patients. Int J Oral Maxillofac Surg. 35(11): 1005-1010, 2006 Nov 23. Poon Choy York, Goh Bee Tin, Myung-Jin Kim, Annabelle Rajaseharan, Shaheen Ahmed, Kobkan Thongprasom, Mantharop Chaimusik, Shirley Suresh, David Machin, Wong Hwee Bee, Jorgen Seldrup, A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102:47-55 24. Kim NK, Lee C, Kang SH, Park JW, Kim MJ, Chang YI,. A three-dimensional analysis of soft and hard tissue changes after a mandibular setback surgery. Comput Meth Programs Biomed 2006;83(3):178-187 25. Kim MJ, Lee JH, Kim YK, Myoung H, Yun PY. The role of tamoxifen in combination with cisplatin on oral squamous cell carcinoma cell lines. Cancer Lett 245(1-2):2084-292. 2007 Jan 26. Baek, Seung-Hak; Lee, Jin-Kyung; Lee, Jong-Ho; Kim, Myung-Jin; Kim, Jong-Ryoul. Comparison of Treatment Outcome and Stability Between Distraction Osteogenesis and LeFort I Osteotomy in Cleft Patients With Maxillary Hypoplasia. Journal of Craniofacial Surgery. 2007;18(5):1209-1215 27. Paeng JY, Lee JH, Lee JH, Kim MJ. Condyle as the point of rotation for 3-D planning of distraction osteogenesis for hemifacial microsomia., J Craniomaxillofac Surg. 2007 Mar;35(2):91-102. 28. Baek SH, Cho IS, Chang YI, Kim MJ. Skeletodental factors affecting chin point deviation in female patients with class III malocclusion and facial asymmetry: a three-dimensional analysis using computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul 24; 29. J.-H. Lee, C.-Y. Chung, H. Myoung, M.-J. Kim, P.-Y. Yun. Gait analysis of donor leg after free fibular flap transfer., Int. J. Oral Maxillofac. Surg. 2008; 37: 625-629 30. Baek SH, Paeng JY, Kim MJ. et al, Trifocal distraction-compression osteosynthesis in conjunction with passive self-ligating brackets for the reconstruction of a large bony defect and multiple missing teeth. American J. Orthodontics and Dentofacial Orthopedics, Vol. 133, (4):601-611, 2008 31. BU-KYU LEE, MI-JUNG KIM, HA-SOON JANG, HEE-RAN LEE, KANG-MIN AHN, JONG-HO LEE, PILL-HOON CHOUNG and MYUNG-JIN KIM A High Concentration of MMP-2/Gelatinase A and MMP-9/Gelatinase B Reduce NK Cell-mediated Cytotoxicity against an Oral Squamous Cell Carcinoma Cell Line., in vivo 22: 593-598 (2008) 32. Won Il Jang, Hong-Gyun Wu, Charn Il Park, Kwang Hyun Kim, Myoung-Whun Sung, Myung-Jin Kim, Pill-Hoon Choung, Jong-Ho Lee, Jin-Yong Choi, Treatment of Patients with Clinically Lymph Node-negative Squamous Cell Carcinoma of the Oral Cavity., Japanese Journal Of Clinical Oncology, 38(6), 2008 33. Yong-Ju OK, Hoon Myoung, Young-Kyun Kim, Jong-Ho Lee, Myung-Jin Kim, Pil-Young Yun Apoptotic effect of CKD-602(Camtobell) on oral squamous cell carcinoma cell lines. Oral Oncol Mar;45(3):266-72 2009, Epub 2008 Aug 19 34. Soung Min KIM, Hoon MYOUNG, Pil Hoon CHOUNG, Myung Jin KIM, Suk Keun Lee, Jong Ho LEE Metastatic leiomyosarcoma in the oral cavity: Case report with protein expression profiles. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY;Dec37(8):454-60 35. Jung YJ, Kim MJ, Baek SH. Hard and soft tissue changes after correction of mandibular prognathism and facial asymmetry by mandibular setback surgery: Three-dimensional analysis using computerized tomography . Oral Surg Oral Med Oral Pathol Oral Radiol Endod ; Jun;107(6):763-771, Epub2009Mar9 36. Kim SM, Myoung H, Lee JH, Kim MJ. Aesthetic contouring of iliac crest donor defect using two titanium plates after harvesting a composite flap. J Plast Reconstr Aesthet Surg; 2009 Jan;62(1):138-40. 37. Sung-Jin Park, Myung-Jin Kim, Yu-Kyoung Kim, Soung-Min Kim, Ju-Yong Park, Hoon MYOUNG Combined cetuimab genistein treatment shows additve anti-cancer effect on oral squamous cell carcinoma. Cancer Letters; 2009 Dec 1 38. Young-Hun Kim, Soung-Min Kim, Yu-Kyoung Kim, Sam-Pyo Hong, Myung-Jin Kim, Hoon Myoung Evaluation of survivin as a prognostic marker in oral squamous cell carcinoma. J Oral pathol Med; Dec;37(8):454-60, 2009 39. Jong-Chul Park, Seung-Ryong Ha, Soung-Min Kim, Myung-Jin-Kim, Jai-Mong Lee, Jong-Ho Lee A randomized clinical I-year trial comparing two types of non-submerged dental implants. Clin Oral Implants Res.; Feb;21(2):228-36. 2010 40. Jong-Chul Park, Hyun-Duck Kim, Soung-Min Kim, Myung-Jin-Kim, Jong-Ho Lee A comparison of implant stability quotients measured using magnetic resonance frequency analysis from two directions: a prospective clinical study during the initial healing period. Clin Oral Implants Res. 2010 Feb 1. 41. Young-Youn Kim, Eun-Jin Lee, Yu-Kyoung Kim, Soon-Min Kim, Ju-YONG Park, Hoon Myoung, Myoung-Jin KIM Anti-Cancer Effects of Celecoxib In Head and Neck Carcinoma. Mol Cells. 2010 Feb;29(2):185-94.